In brief: The Nicene Creed is a Christian statement of faith accepted by the major Christian denominations. It gets its name from the First Council of Nicaea in 325 at which it was adopted. It was later revised in 381. There have been many further creeds, in reaction to further perceived heresy, but this one, as revised in 381 was the very last time both Catholic and Orthodox communions could bring themselves to agree upon a creed.
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